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KMID : 0387820030100020198
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Clinical Pediatric Hematology-Oncology
2003 Volume.10 No. 2 p.198 ~ p.205
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Prevalence of Obesity and Cardiovascular Risk Factors in Survivors of Childhood Acute Lymphoblastic Leukemia
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Lee Yong-Jik
Kim Yong-Han
Hah Jeong-Ok
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Abstract
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Purpose: This study was performed to survey the prevalence of obesity, hypertension, hyperglycemia and dyslipidemia in survivors of childhood acute lymphoblastic leukemia (ALL).
Methods: Retrospective Cohort study of 45 subjects (median age, 15.3 years; median interval after completion of therapy, 5 years) who were diagnosed and treated with ALL and 30 subjects (median age 14 years; median interval after completion of therapy, 5.3 years) with other cancers (control group) at Yeungnam University Hospital from January 1983 to December 1998 was performed. The ratio of male to female was 1.4:1 in the ALL group and 1.7:1 in the control group. Body mass index (BMI), blood pressure, fasting serum glucose and lipids were analyzed. Fourty three of the 45 subjects (96%) with ALL received cranial irradiation and 30 control subjects did not.
Results: Only two of 45 (4.4%) were found to be obese (BMI <95 percentile for age and sex) which was similar to the control group (2/30 subjects, 6.7%). Hypertension was found in only 1 subject (1/45 subjects, 2.2%) with ALL. Dyslipidemia (at least one of high cholesterol, high triglyceride or low high density lipid-cholesterol) was detected in 12 of 39 subjects (30.7%) with ALL and in 8 of 22 subjects (36.4%) with other cancers. No one of either group had hyperglycemia.
Conclusion: Young survivors of childhood ALL do not seem to be at increased risk for obesity, hypertension and hyperglycemia, but seem to be at increased risk for dyslipidemia.
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KEYWORD
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Prevalence, Acute Lymphoblastic Leukemia, Obesity, Hypertension, Hyperglycemia, Dyslipidemia
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